Eikosidyophobia is the irrational fear of the number 22. One numerology site says that the meaning of 22 in name numerology means that fate offers many opportunities for one to go into evil paths, leading to some numerologists to fear the number.
Some other people fear 22 because it adds to 4 (2+2=4), which is an unlucky number in many Asian cultures. Because of that, this phobia may be an offspring of Tetraphobia.